Drug Review: Pyrimethamine

Expression of Target: DHFR

DHFR-TS protein structure
A molecular representation of the dihydrofolate reductase protein. Source: Sinobiological

DHFR's RNA expression is most expressed in immune organs and the blood, followed by the skeletal element which has a moderate level of expression. The protein is highly expressed in the exocrine gland, pharynx, intestines, reproductive organs and structures, oral glands, stomach, lungs, and the pancreas. Its RNA and protein expression in other systems is moderate to low.

DHFR's RNA and baseline expression in different organs.
Chart showing the besline expression of DHFR in different organs. Source: OpenTargets